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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
5 mg | $96 | In Stock | |
10 mg | $165 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $478 | In Stock | |
100 mg | $687 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways. |
In vitro | Sophoraflavanone G (0-100 μM; 24 hours) reduces HL-60 cell viability in a dose-dependent manner and induces apoptosis by activating caspase-3 and caspase-9, downregulating Bcl-2 and Bcl-xL, upregulating Bax, and releasing cytochrome c from mitochondria to cytoplasm, thus promoting apoptosis via the mitochondrially-mediated intrinsic pathway [1]. Additionally, Sophoraflavanone G (0-40 μM; 24 hours) inhibits MDA-MB-231 cell viability with an IC50 of 29.7 μM in a concentration-dependent manner [2]. |
Alias | Kushenol F, Vexibinol |
Molecular Weight | 424.49 |
Formula | C25H28O6 |
Cas No. | 97938-30-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (58.89 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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